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17 March 2023 Microplasma exposure as a novel therapeutic treatment for otitis media demonstrated in a pre-clinical chinchilla model
Guillermo L. Monroy, Jinhong Kim, Alexander Ho, Andrey Mironov, Farzana R. Zaki, Darold R. Spillman Jr., Gabrielle Choo-Kang, Jungeun Won, Peter P. Sun, Edita Aksamitiene, Marina Marjanovic, Eric J. Chaney, Thanh Huong Nguyen, J. Gary Eden, Stephen A. Boppart
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Proceedings Volume PC12358, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2023; PC1235809 (2023) https://doi.org/10.1117/12.2648469
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
Otitis media (OM) is a common middle ear disease that is treated with antibiotics. However, over-prescription of antibiotics heightens the risk of antibiotic resistance. Here, we report the development and testing of a new cold microplasma (CMP) device to treat OM, and demonstrate the translation for in vivo use in a chinchilla animal model. In vitro nontypeable Haemophilus influenzae bacterial and biofilm samples and ex vivo tissue specimens were evaluated for inactivation and injury. CMP-induced effects on any infectious symptoms (middle ear fluid, biofilms) were longitudinally observed with OCT. This represents the first application of CMP treatments for OM therapy.
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Guillermo L. Monroy, Jinhong Kim, Alexander Ho, Andrey Mironov, Farzana R. Zaki, Darold R. Spillman Jr., Gabrielle Choo-Kang, Jungeun Won, Peter P. Sun, Edita Aksamitiene, Marina Marjanovic, Eric J. Chaney, Thanh Huong Nguyen, J. Gary Eden, and Stephen A. Boppart "Microplasma exposure as a novel therapeutic treatment for otitis media demonstrated in a pre-clinical chinchilla model", Proc. SPIE PC12358, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2023, PC1235809 (17 March 2023); https://doi.org/10.1117/12.2648469
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KEYWORDS
Ear
Chemical mechanical planarization
In vitro testing
Optical coherence tomography
Animal model studies
Injuries
Instrument modeling
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