600 kHz A-scan rate enables OCTA-based retinal blood flow speeds quantification at capillary segment level using variable interscan time analysis (VISTA)

Yunchan Hwang; Jungeun Won; Siyu Chen; Antonio Yaghy; Jessica M. Girgis; Kenneth Lam; Nadia K. Waheed; James G. Fujimoto

doi:10.1117/12.2651359

9 March 2023 600 kHz A-scan rate enables OCTA-based retinal blood flow speeds quantification at capillary segment level using variable interscan time analysis (VISTA)

Yunchan Hwang, Jungeun Won, Siyu Chen, Antonio Yaghy, Jessica M. Girgis, Kenneth Lam, Nadia K. Waheed, James G. Fujimoto

Author Affiliations +

Proceedings Volume PC12367, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII; PC123670E (2023) https://doi.org/10.1117/12.2651359
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Retinal capillary blood flow speeds quantification may provide biomarkers for retinal diseases. While OCTA visualizes the retinal vasculature, it provides limited information about the blood flow speeds. We present an OCTA-based method for measuring quantitative surrogate markers for blood flow speeds in retinal capillaries using a temporal autocorrelation decay model, by acquiring multiple OCT B-scan repeats and compiling OCTA measurements both spatially and temporally. A 600 kHz swept light source enabled short and multiple interscan times with fine A-scan spacing. We show blood flow speed differences among retinal vascular plexuses in healthy eyes and alterations in eyes with diabetic retinopathy.

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Yunchan Hwang, Jungeun Won, Siyu Chen, Antonio Yaghy, Jessica M. Girgis, Kenneth Lam, Nadia K. Waheed, and James G. Fujimoto "600 kHz A-scan rate enables OCTA-based retinal blood flow speeds quantification at capillary segment level using variable interscan time analysis (VISTA)", Proc. SPIE PC12367, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII, PC123670E (9 March 2023); https://doi.org/10.1117/12.2651359

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KEYWORDS

Blood circulation

Capillaries

Image segmentation

Retinal scanning

Visualization

Data acquisition

Information visualization

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