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6 March 2023 In-cavity detection of residual cancer during breast-conserving surgery using in vivo quantitative micro-elastography
Peijun Gong, Synn Lynn Chin, Wes Allen, Helen Ballal, James Anstie, Lixin Chin, Hina Ismail, Renate Zilkens, Devina Lakhiani, Matthew McCarthy, Qi Fang, Daniel Firth, Kyle Newman, Caleb Thomas, Jiayue Li, Rowan Sanderson, Ken Foo, Chris Yeomans, Benjamin Dessauvagie, Bruce Latham, Christobel Saunders, Brendan Kennedy
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Proceedings Volume PC12368, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXI; PC1236804 (2023) https://doi.org/10.1117/12.2651033
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
Re-excision following breast-conserving surgery (BCS) due to suspected residual cancer left from the primary surgery causes substantial physical, psychological, and financial burdens for patients. This study provides a first-in-human clinical study of in vivo quantitative micro-elastography (QME) for in-cavity identification of residual cancer. A custom-built handheld QME probe is used to directly scan the surgical cavity for imaging the micro-scale tissue stiffness during BCS. In vivo QME of 21 patients, validated by co-registered histopathology of the excised specimens, demonstrates the capability to detect residual cancer based on its elevated micro-scale stiffness, potentially contributing to a more complete cancer removal.
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Peijun Gong, Synn Lynn Chin, Wes Allen, Helen Ballal, James Anstie, Lixin Chin, Hina Ismail, Renate Zilkens, Devina Lakhiani, Matthew McCarthy, Qi Fang, Daniel Firth, Kyle Newman, Caleb Thomas, Jiayue Li, Rowan Sanderson, Ken Foo, Chris Yeomans, Benjamin Dessauvagie, Bruce Latham, Christobel Saunders, and Brendan Kennedy "In-cavity detection of residual cancer during breast-conserving surgery using in vivo quantitative micro-elastography", Proc. SPIE PC12368, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXI, PC1236804 (6 March 2023); https://doi.org/10.1117/12.2651033
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KEYWORDS
Cancer
Surgery
In vivo imaging
Breast cancer
Tissues
Breast
Diagnostics
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