Multipath contrast of optical coherence tomography for early cancer detection

Jeanie Malone; Adrian Tanskanen; Lien Hoang M.D.; Jessica McAlpine M.D.; Calum MacAulay; Pierre Lane

doi:10.1117/12.2650504

6 March 2023 Multipath contrast of optical coherence tomography for early cancer detection

Jeanie Malone, Adrian Tanskanen, Lien Hoang M.D., Jessica McAlpine M.D., Calum MacAulay, Pierre Lane

Proceedings Volume PC12371, Multimodal Biomedical Imaging XVIII; PC1237107 (2023) https://doi.org/10.1117/12.2650504
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

We hypothesize that there may be cancer-sensitive image biomarkers present in a novel image processing technique. We leverage the multipath artifacts derived from higher order modes that present in double clad fiber-based OCT systems, which are sensitive to scattering angle and as such may be sensitive to sub-resolution features such as nuclear density and size. This work explores multipath contrast in previously collected clinical imaging data; preliminary work has found that this technique can distinguish cancerous and non-cancerous fallopian tube specimens.

Conference Presentation

Citation Download Citation

Jeanie Malone, Adrian Tanskanen, Lien Hoang M.D., Jessica McAlpine M.D., Calum MacAulay, and Pierre Lane "Multipath contrast of optical coherence tomography for early cancer detection", Proc. SPIE PC12371, Multimodal Biomedical Imaging XVIII, PC1237107 (6 March 2023); https://doi.org/10.1117/12.2650504

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