Plasmonic metasurface integrated with multi-well cell culture chamber for metasurface-enhanced Infrared spectroscopy of live cells

Steven H. Huang; Giovanni Sartorello; Po-Ting Shen; Gennady Shvets

doi:10.1117/12.2649369

6 March 2023 Plasmonic metasurface integrated with multi-well cell culture chamber for metasurface-enhanced Infrared spectroscopy of live cells

Steven H. Huang, Giovanni Sartorello, Po-Ting Shen, Gennady Shvets

Author Affiliations +

Proceedings Volume PC12373, Optical Biopsy XXI: Toward Real-Time Spectroscopic Imaging and Diagnosis; PC123730I (2023) https://doi.org/10.1117/12.2649369
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Plasmonic metasurface for surface-enhanced infrared absorption (SEIRA) spectroscopy is integrated with multi-well cell culture chambers for application as a cellular assay based on Fourier transform infrared (FTIR) spectroscopy. Live cells are grown directly on the metasurface, and the enhanced infrared absorption through metasurface plasmonic resonance is probed in reflection mode using a custom-built FTIR-coupled inverted infrared microscope. The application of the proposed device as a cellular assay is demonstrated through the measurement of cellular adhesion with different surface coatings, as well as cellular response to the stimulation of the protease-activated receptors (PARs).

Conference Presentation

Citation Download Citation

Steven H. Huang, Giovanni Sartorello, Po-Ting Shen, and Gennady Shvets "Plasmonic metasurface integrated with multi-well cell culture chamber for metasurface-enhanced Infrared spectroscopy of live cells", Proc. SPIE PC12373, Optical Biopsy XXI: Toward Real-Time Spectroscopic Imaging and Diagnosis, PC123730I (6 March 2023); https://doi.org/10.1117/12.2649369

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