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16 March 2023 Single-shot ultra-high sensitivity imaging of nanometer-sized viruses by common path interferometric microscopy (Conference Presentation)
Samer Alhaddad, Martine Boccara, Ignacio Izeddin, Claude Boccara
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Proceedings Volume PC12391, Label-free Biomedical Imaging and Sensing (LBIS) 2023; PC123910F (2023) https://doi.org/10.1117/12.2650700
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
At Langevin Institute, ESPCI Paris, we have developed a label-free approach to detect and track viruses in aquatic solutions using an interferometric microscopy approach working in transmission. By improving the experimental setup design, we have increased the sensitivity to detect viruses as small as 20nm in diameter, AAV viruses, which are of paramount importance for gene therapy. Furthermore, based on the variation of the interferometric signal along the axial position, we introduce a new way to perform single-shot volumetric imaging which enables high-precision 3D tracking.
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Samer Alhaddad, Martine Boccara, Ignacio Izeddin, and Claude Boccara "Single-shot ultra-high sensitivity imaging of nanometer-sized viruses by common path interferometric microscopy (Conference Presentation)", Proc. SPIE PC12391, Label-free Biomedical Imaging and Sensing (LBIS) 2023, PC123910F (16 March 2023); https://doi.org/10.1117/12.2650700
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KEYWORDS
Interferometry
Viruses
Nanoparticles
Microscopy
Particles
Biomedical optics
Target recognition
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