Combining holography and Raman spectroscopy for cancer-tissue evaluation (Conference Presentation)

Omri Plotnik; Almog Taieb; Garry Berkovic; Miki Haifler; Ori Chehnovsky; Natan Shaked

doi:10.1117/12.2651378

16 March 2023 Combining holography and Raman spectroscopy for cancer-tissue evaluation (Conference Presentation)

Omri Plotnik, Almog Taieb, Garry Berkovic, Miki Haifler, Ori Chehnovsky, Natan Shaked

Proceedings Volume PC12391, Label-free Biomedical Imaging and Sensing (LBIS) 2023; PC123910H (2023) https://doi.org/10.1117/12.2651378
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

We have integrated tissue quantitative phase imaging with Raman spectroscopy, and used it for analyzing benign and malignant cancer tissue samples without staining. We used the acquired stain-free OPD-based texture features of the tissues and deep learning to segment the urothelium layers, where cancer starts from, with the stained tissue as a ground-truth for training. Then, location-guided Raman spectroscopy measurements were acquired from the urothelium according to the segmentation results. We then classified the tissue type based on the location-guided Raman spectroscopy measurement with higher accuracy compared to classifying them without urothelium segmentation.

Conference Presentation

Citation Download Citation

Omri Plotnik, Almog Taieb, Garry Berkovic, Miki Haifler, Ori Chehnovsky, and Natan Shaked "Combining holography and Raman spectroscopy for cancer-tissue evaluation (Conference Presentation)", Proc. SPIE PC12391, Label-free Biomedical Imaging and Sensing (LBIS) 2023, PC123910H (16 March 2023); https://doi.org/10.1117/12.2651378

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