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15 March 2023 Advances in mid-infrared optoacoustic microscopy: Towards non-invasive biomolecular imaging and spectroscopy (Conference Presentation)
Nasire Uluç, Miguel A. Pleitez, Vasilis Ntziachristos
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Proceedings Volume PC12392, Advanced Chemical Microscopy for Life Science and Translational Medicine 2023; PC123920V (2023) https://doi.org/10.1117/12.2656334
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
The detection scheme of conventional mid-infrared (mid-IR) spectroscopy and imaging as well as the strong absorption of water restricts the application of mid-IR spectroscopy/imaging. We applied optoacoustic sensing for the non-invasive retrieval of mid-IR signals in biological tissues and developed Mid-IR Optoacoustic Microscopy (MiROM). This results in a label-free bond-selective microscopy that is able to monitor lipids, proteins, and carbohydrates down to a single-cell level with a lateral resolution of ~5 µm. We will discuss MiROM’s most recent developments for spatiotemporal metabolic monitoring in living cells and tissues as well as perspectives and recent advances for its application in vivo.
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Nasire Uluç, Miguel A. Pleitez, and Vasilis Ntziachristos "Advances in mid-infrared optoacoustic microscopy: Towards non-invasive biomolecular imaging and spectroscopy (Conference Presentation)", Proc. SPIE PC12392, Advanced Chemical Microscopy for Life Science and Translational Medicine 2023, PC123920V (15 March 2023); https://doi.org/10.1117/12.2656334
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KEYWORDS
Imaging spectroscopy
Mid-IR
Spectroscopy
Microscopy
Optoacoustics
In vivo imaging
Proteins
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