Applications of Raman microscopy in cancer biology and drug discovery (Conference Presentation)

Valerie G. Brunton; Martin Lee; Ander Maguregui; Craig Steven; Manasa Ravindra; Romain B. Enjalbert; Michaela Noskova; Steve Hood; Alison N. Hulme; Miguel O. Bernabeu

doi:10.1117/12.2652435

15 March 2023 Applications of Raman microscopy in cancer biology and drug discovery (Conference Presentation)

Valerie G. Brunton, Martin Lee, Ander Maguregui, Craig Steven, Manasa Ravindra, Romain B. Enjalbert, Michaela Noskova, Steve Hood, Alison N. Hulme, Miguel O. Bernabeu

Author Affiliations +

Proceedings Volume PC12392, Advanced Chemical Microscopy for Life Science and Translational Medicine 2023; PC123920Y (2023) https://doi.org/10.1117/12.2652435
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Fast-acquisition Raman methodologies such as stimulated Raman scattering (SRS) and coherent anti-Stokes Raman scattering (CARS) microscopy, which generate image contrast using the Raman active vibrational frequency of a given chemical, provide information on the biochemical composition of tissues. This has enabled detailed imaging of the interaction between tumor cells and the surrounding tumor microenvironment (e.g. tumor vasculature, stromal cells) without the need for additional labelling. In addition, we have developed novel, highly Raman active spectroscopically bioorthogonal labels, for the sensitive and specific intracellular visualisation of small-molecules and cells, allowing monitoring of drug uptake and tracking of individual cell populations.

Conference Presentation

Citation Download Citation

Valerie G. Brunton, Martin Lee, Ander Maguregui, Craig Steven, Manasa Ravindra, Romain B. Enjalbert, Michaela Noskova, Steve Hood, Alison N. Hulme, and Miguel O. Bernabeu "Applications of Raman microscopy in cancer biology and drug discovery (Conference Presentation)", Proc. SPIE PC12392, Advanced Chemical Microscopy for Life Science and Translational Medicine 2023, PC123920Y (15 March 2023); https://doi.org/10.1117/12.2652435

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