3D phononic endo-microscopy of biological matter (Conference Presentation)

Salvatore La Cavera III; Fernando Perez-Cota; Veeren Chauhan; William Hardiman; Mengting Yao; Rafael Fuentes-Dominguez; Kerry Setchfield; Richard J. Smith; Matt Clark

doi:10.1117/12.2648192

16 March 2023 3D phononic endo-microscopy of biological matter (Conference Presentation)

Salvatore La Cavera III, Fernando Perez-Cota, Veeren Chauhan, William Hardiman, Mengting Yao, Rafael Fuentes-Dominguez, Kerry Setchfield, Richard J. Smith, Matt Clark

Author Affiliations +

Proceedings Volume PC12393, Biomedical Applications of Light Scattering XIII; PC1239308 (2023) https://doi.org/10.1117/12.2648192
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

In order to realise the clinical potential of Brillouin scattering-based techniques, it is critical to develop an endoscopic probe for measuring elasticity in future in-vivo environments. We have developed a phonon probe which actively injects high amplitude GHz strain pulses into specimens and have demonstrated proof of concept this technique can be used for high resolution 3D imaging. In this talk we show that this new technology is highly applicable to the 3D elasticity imaging of biological tissue from the single-cell scale to multi-cellular organisms and provides a future pathway for the clinical application of in-vivo Brillouin spectroscopy of tissue.

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Salvatore La Cavera III, Fernando Perez-Cota, Veeren Chauhan, William Hardiman, Mengting Yao, Rafael Fuentes-Dominguez, Kerry Setchfield, Richard J. Smith, and Matt Clark "3D phononic endo-microscopy of biological matter (Conference Presentation)", Proc. SPIE PC12393, Biomedical Applications of Light Scattering XIII, PC1239308 (16 March 2023); https://doi.org/10.1117/12.2648192

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KEYWORDS

In vivo imaging

Light scattering

New and emerging technologies

Optical fibers

Organisms

Phonons

Scattering

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