Targeted fluorescent gold nanocluster for NIR imaging (Conference Presentation)

Hengbo Huang; Julie Prior; Katie Duncan; Rui Tang; Samuel Achilefu

doi:10.1117/12.2649308

17 March 2023 Targeted fluorescent gold nanocluster for NIR imaging (Conference Presentation)

Hengbo Huang, Julie Prior, Katie Duncan, Rui Tang, Samuel Achilefu

Proceedings Volume PC12398, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XIV; PC123980C (2023) https://doi.org/10.1117/12.2649308
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Fluorescent gold nanoclusters (AuNCs) with emission in near infrared (NIR) range have drawn wide attention due to its bright fluorescence, good biocompatibility and photostability. In this work, AuNCs with emission at 800 nm were synthesized through a simple glutathione reduction method through heating. Cyclic RGD peptide will be conjugated through thiol-PEG-amine as targeting ligand. The AuNCs are then used for two photon fluorescent imaging, due to the wide stokes shift. In vivo NIR fluorescent study showed the accumulation of the AuNCs in tumor areas. Moreover, the AuNCs also showed brain uptake, which indicates possible applications in brain imaging.

Conference Presentation

Citation Download Citation

Hengbo Huang, Julie Prior, Katie Duncan, Rui Tang, and Samuel Achilefu "Targeted fluorescent gold nanocluster for NIR imaging (Conference Presentation)", Proc. SPIE PC12398, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XIV, PC123980C (17 March 2023); https://doi.org/10.1117/12.2649308

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KEYWORDS

Near infrared

Gold

Two photon imaging

Microscopes

Natural surfaces

Neuroimaging

Spatial resolution

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