Early detection of cutaneous neurofibromas using spatial frequency domain imaging and optical coherence tomography

Junsoo Lee; Wangcun Jia; Gordon Kennedy; Nitesh Katta; Rafael Sierra; James E. Johnson; Kristen M. Kelly; Anthony J. Durkin; J. Stuart Nelson; Thomas Milner

doi:10.1117/12.3001848

13 March 2024 Early detection of cutaneous neurofibromas using spatial frequency domain imaging and optical coherence tomography

Junsoo Lee, Wangcun Jia, Gordon Kennedy, Nitesh Katta, Rafael Sierra, James E. Johnson, Kristen M. Kelly, Anthony J. Durkin, J. Stuart Nelson, Thomas Milner

Author Affiliations +

Proceedings Volume PC12816, Photonics in Dermatology and Plastic Surgery 2024; PC128160R (2024) https://doi.org/10.1117/12.3001848
Event: SPIE BiOS, 2024, San Francisco, California, United States

Conference Poster

Abstract

Cutaneous neurofibromas (cNF) appear commonly in neurofibromatosis type I (NF1) patients. cNFs usually appear in the skin at puberty and proliferate with increasing numbers and sizes throughout life. If cNFs can be detected and treated in their nascent stage, patient’s quality of life can be improved. To detect early-stage cNF, we have employed spatial frequency domain imaging (SFDI) and optical coherence tomography (OCT). SFDI has been applied to screen large skin areas on eleven cNF subjects. Suspect lesions invisible to the unaided eye but detected using SFDI were imaged with OCT to observe lesion microstructure. Three lesions were biopsied to compare with SFDI and OCT images. Suspect nascent cNFs which are invisible to the unaided eye were detected as low optical scattering regions in all patients. Large area screening using SFDI confirmed scattering contrast between the suspect nascent cNF and the surrounding uninvolved skin. Abnormal disc-shaped structures with reduced scattering regions detected by SFDI were also observed in OCT cross-sections.

Citation Download Citation

Junsoo Lee, Wangcun Jia, Gordon Kennedy, Nitesh Katta, Rafael Sierra, James E. Johnson, Kristen M. Kelly, Anthony J. Durkin, J. Stuart Nelson, and Thomas Milner "Early detection of cutaneous neurofibromas using spatial frequency domain imaging and optical coherence tomography", Proc. SPIE PC12816, Photonics in Dermatology and Plastic Surgery 2024, PC128160R (13 March 2024); https://doi.org/10.1117/12.3001848

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available