Optical coherence tomography and autofluorescence guided biopsy of small airways using a suction-snare biopsy tool

Eric Brace; Jeanie Malone; Adrian Tanskanen; Geoffrey Hohert; Stephen Lam; Calum E. MacAulay; Pierre M. Lane

doi:10.1117/12.3003461

13 March 2024 Optical coherence tomography and autofluorescence guided biopsy of small airways using a suction-snare biopsy tool

Eric Brace, Jeanie Malone, Adrian Tanskanen, Geoffrey Hohert, Stephen Lam, Calum E. MacAulay, Pierre M. Lane

Author Affiliations +

Proceedings Volume PC12820, Endoscopic Microscopy XIX; PC128200H (2024) https://doi.org/10.1117/12.3003461
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Collection of biopsies from the most pathologically advanced region is critical for histopathological assessment of potentially cancerous sites in the lung. However, current applications are limited in their ability to simultaneously image and collect samples in subsegmental airways. We demonstrate a suction-snare device guided with optical coherence tomography and autofluorescence imaging (OCT-AFI) to improve diagnostic yield in these airways. Biopsies collected in healthy ex-vivo porcine airways are shown to retain structural and functional information. Feasibility is demonstrated in an ex-vivo porcine model to assess tissue abnormality prior to biopsy collection.

Conference Presentation

Citation Download Citation

Eric Brace, Jeanie Malone, Adrian Tanskanen, Geoffrey Hohert, Stephen Lam, Calum E. MacAulay, and Pierre M. Lane "Optical coherence tomography and autofluorescence guided biopsy of small airways using a suction-snare biopsy tool", Proc. SPIE PC12820, Endoscopic Microscopy XIX, PC128200H (13 March 2024); https://doi.org/10.1117/12.3003461

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