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13 March 2024 Light functions as the driving mechanism for drug release
Jose Quilez, Tayyaba Hasan, Mohammad A. Saad
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Proceedings Volume PC12823, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXII; PC1282303 (2024) https://doi.org/10.1117/12.3011395
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Pancreatic cancer is the fourth leading cause of cancer deaths. The poor diagnosis, early metastasis, limited drug accumulation in the tumor microenvironment, and acquired resistance to salvage chemotherapeutic cocktails lead to poor clinical outcomes. To overcome this complex problem, personalized combination treatments have been proposed to guide the clinical management of PDAC patients. In this context, we propose the use of novel delivery systems where light is not a mere spectator, but the main character that apart from inducing cytotoxicity also promotes the release of the cargo at the right time in the right place.
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Jose Quilez, Tayyaba Hasan, and Mohammad A. Saad "Light functions as the driving mechanism for drug release", Proc. SPIE PC12823, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXII, PC1282303 (13 March 2024); https://doi.org/10.1117/12.3011395
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KEYWORDS
Cancer
Chemotherapy
Diagnostics
Diseases and disorders
Fluorescence
Nanotechnology
Photoacoustic spectroscopy
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