Multispectral cellular-level imaging of Aβ in the retina

Mircea Mujat; Ankit Patel; John Grimble; Nicusor Iftimia

doi:10.1117/12.3005686

13 March 2024 Multispectral cellular-level imaging of Αβ in the retina

Mircea Mujat, Ankit Patel, John Grimble, Nicusor Iftimia

Proceedings Volume PC12824, Ophthalmic Technologies XXXIV; PC128240E (2024) https://doi.org/10.1117/12.3005686
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

We have developed a multispectral imaging technique for identifying chemical compounds in vivo in the retina with cellular-level resolution and without the use of contrast agents. We combined simultaneous multi-channels offset and confocal AO-SLO imaging, which provides isotropic images of retinal microstructures free of directionality artifacts, with spectral signature analysis of chemical compounds to identify such biomarkers at cellular-level. The new concept has been demonstrated in a model eye using commercially available Aβ. An animal study on a mouse Alzheimer’s model is ongoing. This technique may pave a path forward for better understanding of the onset of various neurodegenerative diseases.

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Mircea Mujat, Ankit Patel, John Grimble, and Nicusor Iftimia "Multispectral cellular-level imaging of Αβ in the retina", Proc. SPIE PC12824, Ophthalmic Technologies XXXIV, PC128240E (13 March 2024); https://doi.org/10.1117/12.3005686

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KEYWORDS

Multispectral imaging

Retina

In vivo imaging

Retinal scanning

Alzheimer's disease

Eye models

Image resolution

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