Monitoring hemodynamics in the mouse retina via ultrafast volumetric spatio-temporal optical coherence tomography (STOC-T)

Wiktor Kulesza; Maciej Wielgo; Piotr Węgrzyn; Sławomir Tomczewski; Onur Centinkaya; Katarzyna Kordecka; Anna Galińska; Bartłomiej Bałamut; Egidijus Auksorius; Andrzej Foik; Robert Zawadzki; Maciej Wojtkowski; Dawid Borycki; Andrea Curatolo

doi:10.1117/12.3005418

13 March 2024 Monitoring hemodynamics in the mouse retina via ultrafast volumetric spatio-temporal optical coherence tomography (STOC-T)

Wiktor Kulesza, Maciej Wielgo, Piotr Węgrzyn, Sławomir Tomczewski, Onur Centinkaya, Katarzyna Kordecka, Anna Galińska, Bartłomiej Bałamut, Egidijus Auksorius, Andrzej Foik, Robert Zawadzki, Maciej Wojtkowski, Dawid Borycki, Andrea Curatolo

Author Affiliations +

Proceedings Volume PC12824, Ophthalmic Technologies XXXIV; PC128241P (2024) https://doi.org/10.1117/12.3005418
Event: SPIE BiOS, 2024, San Francisco, California, United States

Conference Poster

Abstract

We present a novel ultrafast imaging system using Spatio-Temporal Optical Coherence Tomography (STOC-T), capable of acquiring structural images of a mouse retina at a volumetric rate of 112 Hz, aided by a calibrated fundus camera for focal plane adjustment. We extract blood pulse traces from retinal and choroidal vessels using a structural-only OCT analysis, and pulse wave-induced retinal layer displacement from differential OCT phase analysis. With both analyses, we measure hemodynamic parameters, such as the delays between arterial and venous pulsation, to provide a comprehensive suite of potential biomarkers of retinal diseases.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

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Wiktor Kulesza, Maciej Wielgo, Piotr Węgrzyn, Sławomir Tomczewski, Onur Centinkaya, Katarzyna Kordecka, Anna Galińska, Bartłomiej Bałamut, Egidijus Auksorius, Andrzej Foik, Robert Zawadzki, Maciej Wojtkowski, Dawid Borycki, and Andrea Curatolo "Monitoring hemodynamics in the mouse retina via ultrafast volumetric spatio-temporal optical coherence tomography (STOC-T)", Proc. SPIE PC12824, Ophthalmic Technologies XXXIV, PC128241P (13 March 2024); https://doi.org/10.1117/12.3005418

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