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13 March 2024 Fluorescence lifetime imaging for enhanced tumor contrast using exogenous dyes
Anand T, N. Kumar, Rahul Pal, Thinzar M. Lwin, Murali N. Krishnamoorthy, Hannah R. Collins, Corey D. Chan, Andrey Prilutskiy, MacLean P. Nasrallah, Tom H Dijkhuis, Stefan A. Carp, Yin P. Hung, Peter M. Sadow, William C. Faquin, Brian V. Nahed, Allen L. Feng, Kevin S. Emerick, J. Sven D. Mieog, Alexander L. Vahrmeijer, Karthik Rajasekaran, John Y. K. Lee, Kenneth S. Rankin, Santiago Lozano-Calderon, Mark A. Varvares, Kenneth K. Tanabe
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Proceedings Volume PC12825, Molecular-Guided Surgery: Molecules, Devices, and Applications X; PC128250P (2024) https://doi.org/10.1117/12.3002108
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Oncologic surgery can greatly benefit from imaging techniques for the accurate identification of tumor-positive margins both intraoperatively and in resection specimens immediately following surgery. We have demonstrated clinically that fluorescence lifetime can significantly improve the accuracy for tumor vs. normal classification compared to fluorescence intensity in multiple cancer types using tumor targeted agents. Ongoing efforts by our group towards the translation of fluorescence lifetime imaging for intraoperative image guidance using exogenous agents will also be discussed.
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© (2024) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
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Anand T, N. Kumar, Rahul Pal, Thinzar M. Lwin, Murali N. Krishnamoorthy, Hannah R. Collins, Corey D. Chan, Andrey Prilutskiy, MacLean P. Nasrallah, Tom H Dijkhuis, Stefan A. Carp, Yin P. Hung, Peter M. Sadow, William C. Faquin, Brian V. Nahed, Allen L. Feng, Kevin S. Emerick, J. Sven D. Mieog, Alexander L. Vahrmeijer, Karthik Rajasekaran, John Y. K. Lee, Kenneth S. Rankin, Santiago Lozano-Calderon, Mark A. Varvares, and Kenneth K. Tanabe "Fluorescence lifetime imaging for enhanced tumor contrast using exogenous dyes", Proc. SPIE PC12825, Molecular-Guided Surgery: Molecules, Devices, and Applications X, PC128250P (13 March 2024); https://doi.org/10.1117/12.3002108
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KEYWORDS
Tumors
Tissues
Near infrared
Surgery
Fluorescence
Fluorescence lifetime imaging
Fluorescence intensity
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