Frequency domain shortwave infrared spectroscopy for non-invasive measurement of tissue optical properties

Diana Suciu; Thao Pham; Lina Lin; Vipul Chitalia; Darren Roblyer

doi:10.1117/12.3002519

13 March 2024 Frequency domain shortwave infrared spectroscopy for non-invasive measurement of tissue optical properties

Diana Suciu, Thao Pham, Lina Lin, Vipul Chitalia, Darren Roblyer

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Proceedings Volume PC12827, Multiscale Imaging and Spectroscopy V; PC128270N (2024) https://doi.org/10.1117/12.3002519
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

We present here a new technique called Frequency Domain Shortwave Infrared Spectroscopy (FD-SWIRS), which provides absolute broadband optical property extractions as well as tissue water and lipids concentrations using shortwave infrared light. Measurements from a custom digital FD system at 730, 852, 940, and 980 nm were combined with broadband continuous wave (CW) measurements (900 - 1310 nm). FD and CW measurements were integrated using model-based analysis to provide broadband absolute absorption and reduced scattering spectra. Intralipid and heavy water titrations, drift, SNR, a porcine desiccation experiment, and other key experiments were conducted to characterize the system.

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Diana Suciu, Thao Pham, Lina Lin, Vipul Chitalia, and Darren Roblyer "Frequency domain shortwave infrared spectroscopy for non-invasive measurement of tissue optical properties", Proc. SPIE PC12827, Multiscale Imaging and Spectroscopy V, PC128270N (13 March 2024); https://doi.org/10.1117/12.3002519

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KEYWORDS

Infrared spectroscopy

Shortwaves

In vivo imaging

Scattering

Tissues

Absorption

Continuous wave operation

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