Towards multimodal functional imaging of brain dynamics using hybrid near-infrared optoacoustic and fluorescence imaging

Sarah Shaykevich; Russell W. Chan; Kevin C. Chan; Robert E. Campbell; Daniel Razansky; Shy Shoham

doi:10.1117/12.3003298

13 March 2024 Towards multimodal functional imaging of brain dynamics using hybrid near-infrared optoacoustic and fluorescence imaging

Sarah Shaykevich, Russell W. Chan, Kevin C. Chan, Robert E. Campbell, Daniel Razansky, Shy Shoham

Author Affiliations +

Proceedings Volume PC12828, Neural Imaging and Sensing 2024; PC128280C (2024) https://doi.org/10.1117/12.3003298
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Optoacoustic tomography in the first near infrared window (NIR I) can capture much of the mouse brain with high temporal and mesoscale spatial resolutions, making it an excellent candidate for functional neuroimaging experiments. Using fluorescent contrasts which absorb in the NIR I range, we can obtain concurrent or parallel opotacoustic and fluorescence data. Fluorescence information can then be used to validate or augment the optoacoustic data (hybrid fluorescence and optoacoustic tomography, or FLOT). Using the two modalities, we probe functional neural, vascular, and cerebrospinal fluid flow information throughout the brain.

Conference Presentation

Citation Download Citation

Sarah Shaykevich, Russell W. Chan, Kevin C. Chan, Robert E. Campbell, Daniel Razansky, and Shy Shoham "Towards multimodal functional imaging of brain dynamics using hybrid near-infrared optoacoustic and fluorescence imaging", Proc. SPIE PC12828, Neural Imaging and Sensing 2024, PC128280C (13 March 2024); https://doi.org/10.1117/12.3003298

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available