We present a multifunctional tethered capsule endomicroscopy (TCE) system for surveillance and potential treatment of the upper gastrointestinal (GI) tract. The system integrates dual-wavelength OCT imaging operating at 800 nm and 1300 nm, an ultracompact endoscope camera, and an ablation laser. The dual-wavelength OCT enables ultrahigh-resolution imaging of superficial layers (800 nm) as well as deep tissue layers (1300 nm), while the miniature camera provides real-time visualization of the OCT imaged and laser ablation area. The multifunctional imaging and ablation capability of the capsule was demonstrated in vivo on swine models. By combining these functions in a single device, the system offers an effective solution for endoscopic screening, diagnosis, and potential ablation treatment in the GI tract.
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