Dual modal ultrasound localization microscopy and photoacoustic imaging

Shensheng Zhao; Jonathan Hartanto; Ritin Joseph; Cheng-Hsun Wu; Yang Zhao; Yun-Sheng Chen

doi:10.1117/12.3000721

13 March 2024 Dual modal ultrasound localization microscopy and photoacoustic imaging

Shensheng Zhao, Jonathan Hartanto, Ritin Joseph, Cheng-Hsun Wu, Yang Zhao, Yun-Sheng Chen

Proceedings Volume PC12834, Multimodal Biomedical Imaging XIX; PC1283401 (2024) https://doi.org/10.1117/12.3000721
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Photoacoustic (PA) imaging can map the physiological conditions of tissue and track the biodistribution of contrast agents; ultrasound localization microscopy (ULM) with microbubbles provides deep-tissue super-resolution blood vessel images and blood velocity maps. When combined, the dual imaging technique will become a powerful tool with diverse applications. However, longer acquisition time of ULM poses a challenge. To address this, we propose sparsity constraint optimization to accelerate ULM and develop an interleaved PA/fast ULM imaging sequences for the dual imaging. We demonstrate 3D and time-lapse dual imaging with a commonly used linear array imaging system in a mouse model.

Conference Presentation

Citation Download Citation

Shensheng Zhao, Jonathan Hartanto, Ritin Joseph, Cheng-Hsun Wu, Yang Zhao, and Yun-Sheng Chen "Dual modal ultrasound localization microscopy and photoacoustic imaging", Proc. SPIE PC12834, Multimodal Biomedical Imaging XIX, PC1283401 (13 March 2024); https://doi.org/10.1117/12.3000721

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