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13 March 2024 Multipath contrast imaging for oral cancer management
Jeanie Malone, Adrian Tanskanen, Chloe Hill, Kelly Liu, Catherine Poh, Calum MacAulay, Pierre Lane
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Proceedings Volume PC12834, Multimodal Biomedical Imaging XIX; PC1283405 (2024) https://doi.org/10.1117/12.3003322
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Oral cancer management is challenging as many benign lesions present similarly to precancerous lesions; thus, non-invasive optical tools that can assess tissue status would provide utility in lesion monitoring and biopsy site selection. We hypothesize that there may be oral cancer-sensitive image biomarkers present in a novel image processing technique that interrogates angular scattering behaviour (multipath contrast imaging, MCI). This work retrospectively examines MCI of oral lesions imaged with a widefield endoscopic optical coherence tomography and autofluorescence imaging (OCT-AFI) device. Preliminary analysis shows subtle MCI intensity changes dysplasia and distinct visual changes in carcinoma when compared to contralateral.
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Jeanie Malone, Adrian Tanskanen, Chloe Hill, Kelly Liu, Catherine Poh, Calum MacAulay, and Pierre Lane "Multipath contrast imaging for oral cancer management", Proc. SPIE PC12834, Multimodal Biomedical Imaging XIX, PC1283405 (13 March 2024); https://doi.org/10.1117/12.3003322
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KEYWORDS
Cancer
Biopsy
Optical coherence tomography
Tissues
Imaging systems
Fluorescence intensity
Optical sensing
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