Advanced biosensing method through fluorescence enhancement using photonic crystal fiber as optofluidic platform

Baptiste Moeglen Paget; Jayakumar Perumal; Georges Humbert; Dinish U.S.; Malini Olivo

doi:10.1117/12.3001397

13 March 2024 Advanced biosensing method through fluorescence enhancement using photonic crystal fiber as optofluidic platform

Baptiste Moeglen Paget, Jayakumar Perumal, Georges Humbert, Dinish U.S., Malini Olivo

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Proceedings Volume PC12835, Optical Fibers and Sensors for Medical Diagnostics, Treatment, and Environmental Applications XXIV; PC1283509 (2024) https://doi.org/10.1117/12.3001397
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

We report on fluorescence enhancement using a suspended core photonic crystal fiber (PCF) as an optofluidic platform. By employing metallic nanoparticles and an organic spacer, we achieved a thirty-fold signal enhancement of Cy5 dye at picomolar concentrations. The combination of fluorescence enhancement and PCF offers robustness, ease of use, and high sensitivity. This comprehensive study explores fluorescence enhancement using PCF, highlighting the significant enhancement achieved through metallic nanoparticles and organic spacers associated by the long length of light-analyte interactions offered by the PCF. These findings might contribute to the development of highly sensitive optical fiber-platforms for biomedical applications.

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Baptiste Moeglen Paget, Jayakumar Perumal, Georges Humbert, Dinish U.S., and Malini Olivo "Advanced biosensing method through fluorescence enhancement using photonic crystal fiber as optofluidic platform", Proc. SPIE PC12835, Optical Fibers and Sensors for Medical Diagnostics, Treatment, and Environmental Applications XXIV, PC1283509 (13 March 2024); https://doi.org/10.1117/12.3001397

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KEYWORDS

Fluorescence

Optofluidics

Photonic crystal fibers

Biomedical applications

Biosensing

Nanoparticles

Dyes

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