Multispectral imaging of cutaneous water for skin tone insensitive inflammation assessment

Quinlan McGrath; Anmol Jarang; Michael Butler; Leonid Shmuylovich

doi:10.1117/12.3003466

13 March 2024 Multispectral imaging of cutaneous water for skin tone insensitive inflammation assessment

Quinlan McGrath, Anmol Jarang, Michael Butler, Leonid Shmuylovich

Proceedings Volume PC12862, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XV; PC128620J (2024) https://doi.org/10.1117/12.3003466
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Skin disease is primarily diagnosed visually, but this subjective approach can lead to misdiagnosis, particularly for darkly-pigmented patients where increased melanin leads to more subtle disease appearance. Inflammation is characterized by shifts in tissue fluid, and the short-wave infrared (SWIR 900-1700 nm) regime, where water absorbs strongly and melanin absorbs weakly, may therefore be a pigment-insensitive modality for assessing skin inflammation. We built a multispectral SWIR imaging system and tested its ability to detect tissue fluid after intradermal saline injection in 24 healthy subjects with diverse pigmentation. Saline injection regions had 20-50 times more contrast than unaffected skin in SWIR images compared to visible photography, regardless of the degree of pigmentation. SWIR multispectral imaging may offer a new window into assessing inflammatory skin diseases in a pigmentation-independent manner.

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Citation Download Citation

Quinlan McGrath, Anmol Jarang, Michael Butler, and Leonid Shmuylovich "Multispectral imaging of cutaneous water for skin tone insensitive inflammation assessment ", Proc. SPIE PC12862, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XV, PC128620J (13 March 2024); https://doi.org/10.1117/12.3003466

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KEYWORDS

Skin

Short wave infrared radiation

Tissues

Infrared imaging

Infrared radiation

Multispectral imaging

Visualization

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