Non-Invasive portable confocal Raman spectroscopy for comparative biochemical analysis of Atopic Dermatitis and Psoriasis skin

Keertana Vinod Ram; U.S. Dinish; Yik Weng Yew; Renzhe Bi; Amalina Binte Ebrahim Attia; Valerie Teo Xinhui; Poongkulali Rajarahm; Hazel H. Oon; Steven Tien Guan Thng; Malini Olivo

doi:10.1117/12.3022329

20 June 2024 Non-Invasive portable confocal Raman spectroscopy for comparative biochemical analysis of Atopic Dermatitis and Psoriasis skin

Keertana Vinod Ram, U.S. Dinish, Yik Weng Yew, Renzhe Bi, Amalina Binte Ebrahim Attia, Valerie Teo Xinhui, Poongkulali Rajarahm, Hazel H. Oon, Steven Tien Guan Thng, Malini Olivo

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Proceedings Volume PC13006, Biomedical Spectroscopy, Microscopy, and Imaging III; PC1300607 (2024) https://doi.org/10.1117/12.3022329
Event: SPIE Photonics Europe, 2024, Strasbourg, France

Abstract

Atopic dermatitis (AD) and psoriasis are the two most prevalent skin disorders, often assessed through subjective questionnaires or visual evaluations conducted by clinicians, which can be subject to interpersonal variations. This study aims to explore the distinctions between these skin conditions and healthy skin using a portable confocal Raman spectroscopy (CRS) system for objective assessment. Spectral measurements at 671 nm and 785 nm on 9 AD, 6 psoriasis, and 11 healthy subjects reveal lower water content in AD compared to psoriasis and healthy skin. Ceramide subclasses show disease-specific trends, distinguishing AD, and psoriasis. Cholesterol levels further differentiate these conditions, with lower concentrations in lesional AD and significantly higher concentrations in lesional psoriasis compared to healthy skin. These differences contribute to the objective differentiation of skin conditions aiding in thorough assessment and treatment monitoring. Furthermore, it offers valuable insights for developing targeted disease-specific topical treatments.

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Keertana Vinod Ram, U.S. Dinish, Yik Weng Yew, Renzhe Bi, Amalina Binte Ebrahim Attia, Valerie Teo Xinhui, Poongkulali Rajarahm, Hazel H. Oon, Steven Tien Guan Thng, and Malini Olivo "Non-Invasive portable confocal Raman spectroscopy for comparative biochemical analysis of Atopic Dermatitis and Psoriasis skin", Proc. SPIE PC13006, Biomedical Spectroscopy, Microscopy, and Imaging III, PC1300607 (20 June 2024); https://doi.org/10.1117/12.3022329

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KEYWORDS

Skin

Portability

Raman spectroscopy

Biological research

Confocal microscopy

Chromium

Visualization

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