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Chapter 10:
Optical Clearing of Tissues: Benefits for Biology, Medical Diagnostics, and Phototherapy
During the last 25 years, interest in the development and application of optical methods for clinical functional imaging of physiological conditions has been centered around diagnostics and therapy of cancer and other diseases and is growing tremendously. It is initiated by the unique information, relative simplicity, safety, and sufficiently low cost of optical instruments, as compared, e.g., to x-ray computer tomography or magnetic resonance tomography (MRT). However, the main limitation of optical diagnostic methods, including optical diffusion tomography, optical coherence tomography (OCT), confocal microscopy, reflection spectroscopy, etc., is the strong scattering of light in tissues and blood that significantly reduces the contrast, spatial resolution, and probing depth.
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