Preclinical imaging of iridocorneal angle and fundus using a modified integrated flexible handheld probe

Xun Jie Jeesmond Hong; Vengalathunadakal K. Shinoj; Vadakke Matham Murukeshan; Mani Baskaran; Tin Aung

doi:10.1117/1.JMI.4.2.026001

10 April 2017 Preclinical imaging of iridocorneal angle and fundus using a modified integrated flexible handheld probe

Xun Jie Jeesmond Hong, Vengalathunadakal K. Shinoj, Vadakke Matham Murukeshan, Mani Baskaran, Tin Aung

Author Affiliations +

Journal of Medical Imaging, Vol. 4, Issue 2, 026001 (April 2017). https://doi.org/10.1117/1.JMI.4.2.026001

Abstract

A flexible handheld imaging probe consisting of a 3 mm×3 mm charge-coupled device camera, light-emitting diode light sources, and near-infrared laser source is designed and developed. The imaging probe is designed with specifications to capture the iridocorneal angle images and posterior segment images. Light propagation from the anterior chamber of the eye to the exterior is considered analytically using Snell’s law. Imaging of the iridocorneal angle region and fundus is performed on ex vivo porcine samples and subsequently on small laboratory animals, such as the New Zealand white rabbit and nonhuman primate, in vivo. The integrated flexible handheld probe demonstrates high repeatability in iridocorneal angle and fundus documentation. The proposed concept and methodology are expected to find potential application in the diagnosis, prognosis, and management of glaucoma.

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Xun Jie Jeesmond Hong, Vengalathunadakal K. Shinoj, Vadakke Matham Murukeshan, Mani Baskaran, and Tin Aung "Preclinical imaging of iridocorneal angle and fundus using a modified integrated flexible handheld probe," Journal of Medical Imaging 4(2), 026001 (10 April 2017). https://doi.org/10.1117/1.JMI.4.2.026001

Received: 25 January 2017; Accepted: 21 March 2017; Published: 10 April 2017

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KEYWORDS

Eye

Imaging systems

Cornea

Light emitting diodes

Preclinical imaging

Image segmentation

Eye models

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