Clouds’ macrophysical characteristics play an important role in the climate system and dramatically vary because of the diverse climatic and geographic factors in China. We analyze cloud macrophysical characteristics and the differences between subregions in China (18°–54°N, 73°–135°E) from March 2012 to February 2015 based on Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observations, including cloud fractions, cloud vertical distribution, and cloud geometrical properties with the perspective of daytime and nighttime. We found that annual single layer, multilayer (ML), and total cloud fractions are 40.4±1.1%, 22.4±0.4%, and 62.8±1.5%, respectively, and clouds are generally located between 6 and 12 km. The cloud fractions in daytime are less than that in nighttime over the south while that of Tibet shows the reverse trend. In the vertical direction, except for Tibet, the clouds in nighttime have larger spatial coverage and are higher in altitude than that in daytime. The regional average values of cloud macrophysical characteristics in the south are highest, followed successively by Tibet, north, and northwest. Cloud geometrical depth and spacing show a gradually declining trend with the increase in layers and decrease of altitude in ML cloud system.