Chi-squared transform (CST), as a statistical method, can describe the difference degree between vectors. The CST-based methods operate directly on information stored in the difference image and are simple and effective methods for detecting changes in remotely sensed images that have been registered and aligned. However, the technique does not take spatial information into consideration, which leads to much noise in the result of change detection. An improved unsupervised change detection method is proposed based on spatial constraint CST (SCCST) in combination with a Markov random field (MRF) model. First, the mean and variance matrix of the difference image of bitemporal images are estimated by an iterative trimming method. In each iteration, spatial information is injected to reduce scattered changed points (also known as “salt and pepper” noise). To determine the key parameter confidence level in the SCCST method, a pseudotraining dataset is constructed to estimate the optimal value. Then, the result of SCCST, as an initial solution of change detection, is further improved by the MRF model. The experiments on simulated and real multitemporal and multispectral images indicate that the proposed method performs well in comprehensive indices compared with other methods.