Remotely sensed imagery is commonly used to map and monitor large land areas based on the ability to detect vegetation stress. Many sensors are available, including both hyper- and multispectral, but have varying costs, convenience, and characteristics. There were two objectives in this study: (1) to compare a hyperspectral sensor to two multispectral sensors with regards to each sensor’s ability to detect vegetation stress indicators in the visible, red edge, near-infrared, and shortwave infrared portions of the spectrum and (2) to determine the ability of coarser-resolution sensors to detect stress indicators in areas, where a finer resolution sensor detected stress indicators. Pairwise agreements between the sensors were ∼80% in each case, but much of this agreement was a function of agreement where stress indicators were absent. Spatial sensitivity analysis supported a conclusion that coarser-resolution sensors were consistently able to detect stress indicators in areas much smaller than their pixel size.