In-orbit verification of the coregistration of channels in a scanning microwave or infrared radiometer can in principle be done during normal in-orbit operation, using the regular events of lunar intrusion in the instrument cold space calibration view. A technique of data analysis based on best fit of data across lunar intrusions has been used to check the mutual alignment of the spectral channels of the microwave humidity sounder (MHS) instrument. MHS is a cross-track scanning radiometer in the millimeter-wave range flying on EUMETSAT and NOAA polar satellites, used operationally for the retrieval of atmospheric parameters in numerical weather prediction and nowcasting. This technique does not require any special operation or maneuver and only relies on the analysis of data from the nominal scanning operation. The coalignment of sounding channels and window channels can be evaluated by this technique, which would not be possible using Earth landmarks, due to the absorption effect of the atmosphere. The analysis reported shows an achievable accuracy below 0.5 mrad against a beam width at 3 dB and spatial sampling interval of about 20 mrad. In-orbit results for the MHS instrument on Metop-B are also compared with the prelaunch instrument characterization, showing a good correlation.