Hyperspectral infrared remote sensing can provide the information about temperature and humidity of the atmosphere at high vertical resolution and high accuracy. To assimilate its radiances directly, we must correct biases between the observed radiances and the simulated ones from the model first guess, caused by systematic error of radiances and by the radiative transfer model and assimilating system. The method used for bias correction was developed for global models, and its adaptation to regional models raises further questions. This study is based on coupling the mesoscale numerical model weather research and forecast and gridpoint statistical interpolation assimilation system, using adaptive variational bias correction (VarBC) to the scan angle and air-mass factor, and investigates the characteristics of bias correction coefficients for the regional model. It was found that advanced infrared sounder (AIRS) channels located in the 15-μm CO2 absorption band had large scan bias, and that its nadir bias had a time dependence, which is probably due to the bias from the radiative transfer model. By contrast, other channels had small scan bias and weak time dependence. In air-mass bias correction, predictors of zenith and temperature lapse rate had huge oscillations due to variations in data coverage from the regional models. The effect of this scheme on correction in a regional model was verified via the histogram analysis of innovation. The verification showed that correction on most of the channels got satisfactory results except for several land surface channels. The corrected histogram satisfied the requirement of an unbiased normal distribution. In a typhoon forecast experiment, the influence of radiance bias correction on forecast result was tested. It showed that, compared with parameters from the global model, regional radiance correction parameters study improved the prediction of the typhoon 72-h forecast.