Tropospheric NO2 concentrations obtained from the measurements of the Ozone Monitoring Instrument on board the NASA Aura satellite from 2005 to 2016 were studied to identify major NO2 emission hot spots, trends, and seasonal variations over Kazakhstan. Emission hot spots are observed over the locations of thermal power plants (Ekibastuz) and major urban and industrial regions (Almaty and Shymkent), as well as the capital city (Astana). Some decreasing trends have been observed for NO2 over Ekibastuz, whereas the regions of Almaty and Shymkent showed increasing trends due to industrial growth. The seasonal pattern of the NO2 concentration shows a difference between three industrial cities of Almaty, Shymkent, and Ekibastuz versus the rest of Kazakhstan. In these three cities, a NO2 maximum is found during wintertime, which we attribute to seasonality of emissions associated with electricity production and the longer chemical lifetime of NO2 in winter. In contrast, in Astana and the rest of Kazakhstan, the NO2 concentration reaches a maximum in the summer.