1 October 1996 Retinopathy of prematurity and induced changes in arterial oxygen saturation with near infrared spectrophotometry: a retrospective cohort study
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J. of Biomedical Optics, 1(4), (1996). doi:10.1117/12.250683
Abstract
Near infrared spectrophotometry (NIRS) is a noninvasive method for measuring oxygenated and deoxygenated hemoglobin in the neonatal brain. Using oxygen as a tracer, it is possible to calculate cerebral blood flow (cbf) and hemoglobin concentration (cHbc), which corresponds to cerebral blood volume, by inducing small changes in arterial oxygen saturation (SaO2). Variability of tcpO2 is considered to be associated with severe retinopathy of prematurity (ROP). A preliminary analysis without control found a 51% incidence of ROP in infants subjected to NIRS measurements whereas among infants who were not exposed to oxygen changes, only 29% developed ROP (stages 1 to 4, p50.008). A controlled study (retrospective cohort study) with matched pairs was performed. Thirty-nine premature newborns who had received NIRS recordings were matched with 39 out of 172 infants who had not received NIRS. Using this controlled study design there was no difference in the incidence and severity of ROP between the two groups. The conclusions are that: (1) Small changes in oxygen saturation of 3 to 10% to measure cbf and cHbc did not increase the incidence or the degree of severity of ROP. (2) A controlled study design is important. Analyses of uncontrolled data would have led to the conclusion that oxygen changes as used with NIRS increase the risk of ROP.
Kurt von Siebenthal, Matthias Keel, Vera Dietz, J. C. Fauchere, X. Martin, Martin Wolf, G. Duc, Hans Ulrich Bucher, "Retinopathy of prematurity and induced changes in arterial oxygen saturation with near infrared spectrophotometry: a retrospective cohort study," Journal of Biomedical Optics 1(4), (1 October 1996). https://doi.org/10.1117/12.250683
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