Optimal design of structured nanospheres for ultrasharp light-scattering resonances as molecular imaging multilabels

Kun Chen; Yang Liu; Guillermo Ameer; Vadim Backman

doi:10.1117/1.1899684

1 March 2005 Optimal design of structured nanospheres for ultrasharp light-scattering resonances as molecular imaging multilabels

Kun Chen, Yang Liu, Guillermo Ameer, Vadim Backman

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Journal of Biomedical Optics, Vol. 10, Issue 2, 024005 (March 2005). https://doi.org/10.1117/1.1899684

Abstract

Optical molecular imaging could potentially enable noninvasive high-resolution characterization and diagnosis of living tissue. The capability to image multiple molecular targets simultaneously is particularly important. Currently this task cannot be achieved using conventional optical contrast agents, due to their broad spectral responses (~80 to 200 nm). Developments in research on semiconductor nanocrystals (quantum dots) provide one possible solution. We describe a different concept of multilabel molecular imaging that utilizes resonant light-scattering spectroscopy of multilayered nanospheres to achieve tunable ultrasharp resonance peaks with widths as narrow as 10 nm. Our theoretical study demonstrates that dozens of molecular targets can potentially be imaged simultaneously using this approach.

©(2005) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Kun Chen, Yang Liu, Guillermo Ameer, and Vadim Backman "Optimal design of structured nanospheres for ultrasharp light-scattering resonances as molecular imaging multilabels," Journal of Biomedical Optics 10(2), 024005 (1 March 2005). https://doi.org/10.1117/1.1899684

Published: 1 March 2005

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Cited by 44 scholarly publications and 8 patents.

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KEYWORDS

Nanoparticles

Light scattering

Molecular imaging

Silica

Gold

Silver

Tissues

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