1 July 2005 Advantages of multi-color fluorescent proteins for whole-body and in vivo cellular imaging
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Abstract
The revolution of in vivo cancer biology enabled by fluorescent proteins is described. The high extinction coefficients, quantum yields, and unique spectral properties of fluorescent proteins have been taken advantage of in order to visualize, in real time, the important aspects of cancer in living animals, including tumor cell trafficking, invasion, metastasis, and angiogenesis. Fluorescent proteins enable whole-body imaging of tumors on internal organs. These multicolored proteins have allowed the color-coding of cancer cells growing in vivo with distinction of different cell types, including host from tumor, with single-cell resolution.
© (2005) Society of Photo-Optical Instrumentation Engineers (SPIE)
Robert M. Hoffman, Robert M. Hoffman, } "Advantages of multi-color fluorescent proteins for whole-body and in vivo cellular imaging," Journal of Biomedical Optics 10(4), 041202 (1 July 2005). https://doi.org/10.1117/1.1992485 . Submission:
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