1 May 2006 Three-dimensional imaging of skin melanoma in vivo by dual-wavelength photoacoustic microscopy
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Abstract
Dual-wavelength reflection-mode photoacoustic microscopy is used to noninvasively obtain three-dimensional (3-D) images of subcutaneous melanomas and their surrounding vasculature in nude mice in vivo. The absorption coefficients of blood and melanin-pigmented melanomas vary greatly relative to each other at these two optical wavelengths (764 and 584 nm). Using high-resolution and high-contrast photoacoustic imaging in vivo with a near-infrared (764-nm) light source, the 3-D melanin distribution inside the skin is imaged, and the maximum thickness of the melanoma (~0.5 mm) is measured. The vascular system surrounding the melanoma is also imaged with visible light (584 nm) and the tumor-feeding vessels found. This technique can potentially be used for melanoma diagnosis, prognosis, and treatment planning.
© (2006) Society of Photo-Optical Instrumentation Engineers (SPIE)
Jung-Taek Oh, Meng-Lin Li, Hao F. Zhang, Konstantin Maslov, Lihong V. Wang, "Three-dimensional imaging of skin melanoma in vivo by dual-wavelength photoacoustic microscopy," Journal of Biomedical Optics 11(3), 034032 (1 May 2006). https://doi.org/10.1117/1.2210907 . Submission:
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