1 September 2006 Doppler optical coherence microscopy for studies of cochlear mechanics
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Abstract
The possibility of measuring subnanometer motions with micron scale spatial resolution in the intact mammalian cochlea using Doppler optical coherence microscopy (DOCM) is demonstrated. A novel DOCM system is described that uses two acousto-optic modulators to generate a stable 500-kHz heterodyne frequency. Images and motion measurements are obtained using phase-resolved analysis of the interference signal. The DOCM system permits imaging with micron-scale resolution and 85-dB sensitivity and motion measurements with 100-kHz bandwidth, directional discrimination, and 30-pm/Hz0.5 noise floor. Images and motion measurements are presented that demonstrate the ability to resolve motions of structures of interest in a mammalian cochlea in vitro including the basilar membrane, reticular lamina, tectorial membrane, and outer hair cells.
© (2006) Society of Photo-Optical Instrumentation Engineers (SPIE)
Stanley S. Hong, Stanley S. Hong, Dennis M. Freeman, Dennis M. Freeman, } "Doppler optical coherence microscopy for studies of cochlear mechanics," Journal of Biomedical Optics 11(5), 054014 (1 September 2006). https://doi.org/10.1117/1.2358702 . Submission:
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