1 September 2006 Noise contribution to the correlation between temperature-induced localized reflectance of diabetic skin and blood glucose
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Abstract
We used the effect of temperature on the localized reflectance of human skin to assess the role of noise sources on the correlation between temperature-induced fractional change in optical density of human skin (ODT) and blood glucose concentration [BG]. Two temperature-controlled optical probes at 30°C contacted the skin, one was then cooled by –10°C; the other was heated by +10°C. ODT upon cooling or heating was correlated with capillary [BG] of diabetic volunteers over a period of three days. Calibration models in the first two days were used to predict [BG] in the third day. We examined the conditions where the correlation coefficient (R2) for predicting [BG] in a third day ranked higher than R2 values resulting from fitting permutations of randomized [BG] to the same ODT values. It was possible to establish a four-term linear regression correlation between ODT upon cooling and [BG] with a correlation coefficient higher than that of an established noise threshold in diabetic patients that were mostly females with less than 20 years of diabetes duration. The ability to predict [BG] values with a correlation coefficient above biological and body-interface noise varied between the cases of cooling and heating.
© (2006) Society of Photo-Optical Instrumentation Engineers (SPIE)
Michael G. Lowery, Michael G. Lowery, Brenda Calfin, Brenda Calfin, Shu-Jen Yeh, Shu-Jen Yeh, Tao Doan, Tao Doan, Eric B. Shain, Eric B. Shain, Charles F. Hanna, Charles F. Hanna, Ronald Hohs, Ronald Hohs, Stanislaw Kantor, Stanislaw Kantor, John Lindberg, John Lindberg, Omar S. Khalil, Omar S. Khalil, } "Noise contribution to the correlation between temperature-induced localized reflectance of diabetic skin and blood glucose," Journal of Biomedical Optics 11(5), 054029 (1 September 2006). https://doi.org/10.1117/1.2360529 . Submission:
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