1 September 2006 In vivo high-speed imaging of individual cells in fast blood flow
Author Affiliations +
J. of Biomedical Optics, 11(5), 054034 (2006). doi:10.1117/1.2355666
In vivo, label-free, high-speed (up to 10,000 with the potential for 40,000 frames per second), high-resolution (up to 300 nm) real-time continuous imaging with successive framing of circulating individual erythrocytes, leukocytes, and platelets in fast blood flow is developed. This technique, used in an animal model, reveals the extremely high dynamic deformability of erythrocytes in natural flow. Potential applications of this technique are discussed with focus on time-resolved monitoring of the cell deformation dynamics in the native biological environment, which may have diagnostic value for the early diagnosis of diseases.
Vladimir P. Zharov, Ekaterina I. Galanzha, Yulian A. Menyaev, Valery V. Tuchin, "In vivo high-speed imaging of individual cells in fast blood flow," Journal of Biomedical Optics 11(5), 054034 (1 September 2006). https://doi.org/10.1117/1.2355666

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