1 November 2006 Cell membrane and gold nanoparticles effects on optical immersion experiments with noncancerous and cancerous cells: finite-difference time-domain modeling
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J. of Biomedical Optics, 11(6), 064037 (2006). doi:10.1117/1.2400239
Abstract
Pilot results on the application of the finite-difference time-domain (FDTD) approach for studying the implementation of the optical immersion technique for the visualization of single and multiple gold nanoparticles in biological cells are presented. We focus on two different scenarios considering single biological cells containing (1) cytoplasm, nucleus, and membrane and (2) cytoplasm, nucleus, gold nanoparticles, and membrane. To the best of our knowledge, this is the first time the cell membrane thickness and gold nanoparticle effects on the forward scattered light from biological cells are discussed. The applicability and the potential of the FDTD approach for studying optical immersion technique enhanced bioimaging is demonstrated.
Stoyan Tanev, Valery V. Tuchin, Paul Paddon, "Cell membrane and gold nanoparticles effects on optical immersion experiments with noncancerous and cancerous cells: finite-difference time-domain modeling," Journal of Biomedical Optics 11(6), 064037 (1 November 2006). http://dx.doi.org/10.1117/1.2400239
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KEYWORDS
Nanoparticles

Gold

Finite-difference time-domain method

Near field

Biomedical optics

Light scattering

Near field optics

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