1 March 2007 Real-time microscopic visualization of tissue response to laser thermal therapy
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J. of Biomedical Optics, 12(2), 020501 (2007). doi:10.1117/1.2714027
Abstract
We present methods for visualizing the dynamic response of biological samples to laser-induced heating. Our approach utilizes optical frequency-domain imaging to detect, spatially localize, and monitor unique dynamic signatures that arise within zones of active tissue denaturation. Since this information is precisely registered with high-resolution (~10 µm) cross sectional images, regions of thermally destroyed tissue can be mapped in relation to pre-existing morphology. Using porcine esophageal specimens ex vivo, we demonstrate that the extent and evolution of laser thermal damage can be assessed in real time.
Benjamin J. Vakoc, Guillermo J. Tearney, Brett E. Bouma, "Real-time microscopic visualization of tissue response to laser thermal therapy," Journal of Biomedical Optics 12(2), 020501 (1 March 2007). http://dx.doi.org/10.1117/1.2714027
Submission: Received ; Accepted
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KEYWORDS
Laser therapeutics

Tissues

Laser tissue interaction

Tissue optics

Visualization

Injuries

Phase measurement

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