1 March 2007 Intracellularly grown gold nanoparticles as potential surface-enhanced Raman scattering probes
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J. of Biomedical Optics, 12(2), 020502 (2007). doi:10.1117/1.2717549
Abstract
Gold nanoparticles grown within the intracellular confines of living cells are introduced as potential surface-enhanced Raman scattering (SERS) substrates for confocal Raman spectrometry. Electron microscopy and a silver-enhanced reflectance laser scanning confocal microscopic approach were used to visualize the size, shape, and distribution of intracellularly grown gold nanoparticles (IGAuN) as small as 1 nm. Passive uptake as the conventional approach for delivering nanoparticles inside cells faces the insurmountable challenge of escaping the endosomal/lysosomal pathway. In contrast, IGAuN provides an unprecedented advantage of providing access to cytoplasm and nucleus.
Ali Shamsaie, Magdalena Jonczyk, Jennifer D. Sturgis, J. Paul Robinson, Joseph Irudayaraj, "Intracellularly grown gold nanoparticles as potential surface-enhanced Raman scattering probes," Journal of Biomedical Optics 12(2), 020502 (1 March 2007). http://dx.doi.org/10.1117/1.2717549
Submission: Received ; Accepted
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KEYWORDS
Nanoparticles

Gold

Confocal microscopy

Proteins

Raman spectroscopy

Surface enhanced Raman spectroscopy

Raman scattering

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