1 January 2007 Perturbation and differential Monte Carlo methods for measurement of optical properties in a layered epithelial tissue model
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Abstract
The use of perturbation and differential Monte Carlo (pMC/dMC) methods in conjunction with nonlinear optimization algorithms were proposed recently as a means to solve inverse photon migration problems in regionwise heterogeneous turbid media. We demonstrate the application of pMC/dMC methods for the recovery of optical properties in a two-layer extended epithelial tissue model from experimental measurements of spatially resolved diffuse reflectance. The results demonstrate that pMC/dMC methods provide a rapid and accurate approach to solve two-region inverse photon migration problems in the transport regime, that is, on spatial scales smaller than a transport mean free path and in media where optical scattering need not dominate absorption. The pMC/dMC approach is found to be effective over a broad range of absorption (50 to 400%) and scattering (70 to 130%) perturbations. The recovery of optical properties from spatially resolved diffuse reflectance measurements is examined for different sets of source-detector separation. These results provide some guidance for the design of compact fiber-based probes to determine and isolate optical properties from both epithelial and stromal layers of superficial tissues.
© (2007) Society of Photo-Optical Instrumentation Engineers (SPIE)
InSeok Seo, Joon Shik You, Carole Hayakawa, Vasan Venugopalan, "Perturbation and differential Monte Carlo methods for measurement of optical properties in a layered epithelial tissue model," Journal of Biomedical Optics 12(1), 014030 (1 January 2007). https://doi.org/10.1117/1.2697735 . Submission:
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