1 January 2007 Perturbation and differential Monte Carlo methods for measurement of optical properties in a layered epithelial tissue model
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J. of Biomedical Optics, 12(1), 014030 (2007). doi:10.1117/1.2697735
Abstract
The use of perturbation and differential Monte Carlo (pMC/dMC) methods in conjunction with nonlinear optimization algorithms were proposed recently as a means to solve inverse photon migration problems in regionwise heterogeneous turbid media. We demonstrate the application of pMC/dMC methods for the recovery of optical properties in a two-layer extended epithelial tissue model from experimental measurements of spatially resolved diffuse reflectance. The results demonstrate that pMC/dMC methods provide a rapid and accurate approach to solve two-region inverse photon migration problems in the transport regime, that is, on spatial scales smaller than a transport mean free path and in media where optical scattering need not dominate absorption. The pMC/dMC approach is found to be effective over a broad range of absorption (50 to 400%) and scattering (70 to 130%) perturbations. The recovery of optical properties from spatially resolved diffuse reflectance measurements is examined for different sets of source-detector separation. These results provide some guidance for the design of compact fiber-based probes to determine and isolate optical properties from both epithelial and stromal layers of superficial tissues.
InSeok Seo, Joon Shik You, Carole Hayakawa, Vasan Venugopalan, "Perturbation and differential Monte Carlo methods for measurement of optical properties in a layered epithelial tissue model," Journal of Biomedical Optics 12(1), 014030 (1 January 2007). http://dx.doi.org/10.1117/1.2697735
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KEYWORDS
Optical properties

Scattering

Tissue optics

Sensors

Absorption

Monte Carlo methods

Tissues

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