1 March 2007 Probing the low-frequency vibrational modes of viruses with Raman scattering—bacteriophage M13 in water
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J. of Biomedical Optics, 12(2), 024009 (2007). doi:10.1117/1.2718935
Abstract
Raman spectroscopy is used to study low-wave-number (≤20 cm-1) acoustic vibrations of the M13 phage. A well-defined Raman line is observed at around 8.5 cm-1. The experimental results are compared with theoretical calculations based on an elastic continuum model and appropriate Raman selection rules derived from a bond polarizability model. The observed Raman mode is shown to belong to one of the Raman-active axial modes of the M13 phage protein coat. It is expected that the detection and characterization of this low-frequency vibrational mode can be used for applications in biomedical nanotechnology such as for monitoring the process of virus functionalization and self-assembly.
Kong-Thon Tsen, Eric C. Dykeman, Otto F. Sankey, Shaw-Wei D. Tsen, Nien-Tsung Lin, Juliann G. Kiang, "Probing the low-frequency vibrational modes of viruses with Raman scattering—bacteriophage M13 in water," Journal of Biomedical Optics 12(2), 024009 (1 March 2007). http://dx.doi.org/10.1117/1.2718935
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KEYWORDS
Raman spectroscopy

Raman scattering

Viruses

Proteins

Thin film coatings

Polarizability

Polarization

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