1 March 2007 Nonlinear optical interference of two successive coherent anti-Stokes Raman scattering signals for biological imaging applications
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Abstract
The nonlinear optical interference of two successively generated coherent anti-Stokes Raman scattering (CARS) signals from two different samples placed in series is demonstrated for the imaging performance, in which a collinear phase matching geometry is used. The relative phase of two CARS signals is controlled by a phase-shifting unit made of dispersive glass materials of which the thickness can be precisely varied. The clear interference fringes are observed as the thickness of the phase-shifting unit changes. The interference effect is then utilized to achieve a better quality CARS image of a biological tissue taken from a mouse skin. Placing the tissue in the second sample position and performing raster scans of the laser beams on it, we can acquire a CARS image of higher contrast compared to the normal image obtained without interferometric implementation.
© (2007) Society of Photo-Optical Instrumentation Engineers (SPIE)
Eunseong Lee, Eunseong Lee, Jae Yong Lee, Jae Yong Lee, Yong Shim Yoo, Yong Shim Yoo, } "Nonlinear optical interference of two successive coherent anti-Stokes Raman scattering signals for biological imaging applications," Journal of Biomedical Optics 12(2), 024010 (1 March 2007). https://doi.org/10.1117/1.2718560 . Submission:
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