1 March 2007 Cortical blood flow assessment with frequency-domain laser Doppler microscopy
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J. of Biomedical Optics, 12(2), 024019 (2007). doi:10.1117/1.2715184
Abstract
We report the assessment of cerebral blood flow (CBF) changes with a wide-field laser Doppler imager based on a CCD camera detection scheme, in vivo, in mice. The setup enables the acquisition of data in minimally invasive conditions. In contrast with conventional laser Doppler velocimeters and imagers, the Doppler signature of moving scatterers is measured in the frequency domain, by detuning a heterodyne optical detection. The quadratic mean of the measured frequency shift is used as an indicator of CBF. We observe a significant variability of this indicator in an experiment designed to induce blood flow changes.
Michael Atlan, Benoît Claude Forget, Claude Boccara, Tania Vitalis, Armelle Rancillac, Andrew K. Dunn, Michel Gross, "Cortical blood flow assessment with frequency-domain laser Doppler microscopy," Journal of Biomedical Optics 12(2), 024019 (1 March 2007). http://dx.doi.org/10.1117/1.2715184
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KEYWORDS
Doppler effect

Blood circulation

In vivo imaging

Brain

Light scattering

Laser Doppler velocimetry

Blood vessels

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