Optical sensor for interstitial pH measurements

Francesco Baldini; Ambra Giannetti; Andrea Azelio Mencaglia

doi:10.1117/1.2714807

1 March 2007 Optical sensor for interstitial pH measurements

Francesco Baldini; Ambra Giannetti; Andrea Azelio Mencaglia;

Author Affiliations +

J. of Biomedical Optics, 12(2), 024024 (2007). doi:10.1117/1.2714807

Abstract

An optical fiber sensor for measuring the pH in interstitial fluid is described. Microdialysis is the approach followed for extracting the sample from the subcutaneous adipose tissue. The interstitial fluid drawn flows through a microfluidic circuit formed by a microdialysis catheter in series with a pH glass capillary. The pH indicator (phenol red) is covalently immobilized on the internal wall of the glass capillary. An optoelectronic unit that makes use of LEDs and photodetectors is connected to the sensing capillary by means of optical fibers. Optical fibers are used to connect the interrogating unit to the sensing capillary. A resolution of 0.03 pH units and an accuracy of 0.07 pH units are obtained. Preliminary in vivo tests are carried out in pigs with altered respiratory function.

Citation Download Citation

Francesco Baldini, Ambra Giannetti, Andrea Azelio Mencaglia, "Optical sensor for interstitial pH measurements," Journal of Biomedical Optics 12(2), 024024 (1 March 2007). https://doi.org/10.1117/1.2714807

ACCESS THE FULL ARTICLE

PERSONAL SIGN IN
Full access may be available with your subscription

Email or Username Forgot your username?

Password Forgot your password?

Show

Remember Email/Username on this computer

Remember Password

No SPIE account? Create an account
or Institutional Sign In via Shibboleth

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $20.00

Non-members: $25.00 ADD TO CART

Show All Keywords

Keywords/Phrases

Search In:

Publication Years