1 May 2007 Performance of an exhaled nitric oxide and carbon dioxide sensor using quantum cascade laser-based integrated cavity output spectroscopy
Author Affiliations +
J. of Biomedical Optics, 12(3), 034034 (2007). doi:10.1117/1.2747608
Abstract
Exhaled nitric oxide (NO) is an important biomarker in asthma and other respiratory disorders. The optical performance of a NO/CO2 sensor employing integrated cavity output spectroscopy (ICOS) with a quantum cascade laser operating at 5.22 μm capable of real-time NO and CO2 measurements in a single breath cycle is reported. A NO noise-equivalent concentration of 0.4 ppb within a 1-sec integration time is achieved. The off-axis ICOS sensor performance is compared to a chemiluminescent NO analyzer and a nondispersive infrared (NDIR) CO2 absorption capnograph. Differences between the gas analyzers are assessed by the Bland-Altman method to estimate the expected variability between the gas sensors. The off-axis ICOS sensor measurements are in good agreement with the data acquired with the two commercial gas analyzers. This work demonstrates the performance characteristics and merits of mid-infrared spectroscopy for exhaled breath analysis.
Matthew R. McCurdy, Yury A. Bakhirkin, Gerard Wysocki, Frank K. Tittel, "Performance of an exhaled nitric oxide and carbon dioxide sensor using quantum cascade laser-based integrated cavity output spectroscopy," Journal of Biomedical Optics 12(3), 034034 (1 May 2007). http://dx.doi.org/10.1117/1.2747608
JOURNAL ARTICLE
9 PAGES


SHARE
KEYWORDS
Sensors

Carbon monoxide

NOx

Quantum cascade lasers

Chemiluminescence

Calibration

Statistical analysis

Back to Top