Three-dimensional nonlinear optical endoscopy

Ling Fu; Ankur Jain; Charles Cranfield; Huikai Xie; Min Gu

doi:10.1117/1.2756102

1 July 2007 Three-dimensional nonlinear optical endoscopy

Ling Fu, Ankur Jain, Charles Cranfield, Huikai Xie, Min Gu

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Journal of Biomedical Optics, Vol. 12, Issue 4, 040501 (July 2007). https://doi.org/10.1117/1.2756102

Abstract

The development of miniaturized nonlinear optical microscopy or endoscopy is essential to complement the current imaging modalities for diagnosis and monitoring of cancers. We report on a nonlinear optical endoscope based on a double-clad photonic crystal fiber and a two-dimensional (2-D) microelectromechanical system mirror, enabling the three-dimensional (3-D) nonlinear optical imaging through in vitro gastrointestinal tract tissue and human breast cancer tissue with a penetration depth of approximately 100 μm and axial resolution of 10 μm. The 3-D high-resolution and high-sensitive imaging ability of the nonlinear optical endoscope facilitates the visualization of 3-D morphologic and cell nuclei arrangement within tissue, and therefore will be important for histopathologic interpretation without the need of tissue excision.

©(2007) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Ling Fu, Ankur Jain, Charles Cranfield, Huikai Xie, and Min Gu "Three-dimensional nonlinear optical endoscopy," Journal of Biomedical Optics 12(4), 040501 (1 July 2007). https://doi.org/10.1117/1.2756102

Published: 1 July 2007

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